Anna Pedrinolla, Masoud Isanejad, Cinzia Antognelli, Desirée Bartolini, Consuelo Borras, Valentina Cavedon, Gabriele Di Sante, Anna Migni, Cristina Mas-Bargues, Chiara Milanese, Claudia Baschirotto, Roberto Modena, Alessandra Pistilli, Mario Rende, Federico Schena, Anna Maria Stabile, Nicola Vincenzo Telesa, Sara Tortorella, Kay Hemmings, Jose Vina, Eivind Wang, Anne McArdle, Malcolm J Jackson, Massimo Venturelli, Francesco Galli

Abstract

Objective Protein–energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols (PP), in combination with muscle anabolic effect of adequate dietary protein intake and physical exercise to prevent the age-dependent decline of muscle mass and its key underpinning mechanisms including mitochondrial function, and nutrient metabolism in muscle in the elderly.